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Related Experiment Video

Updated: Feb 7, 2026

A Microfluidic Chip for ICPMS Sample Introduction
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[Introduction].

Yoshiyuki Yamaguchi1, Yosuke Katata, Makoto Okawaki

  • 1Dept. of Clinical Oncology, Kawasaki Medical School.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 26, 2018
PubMed
Summary

Immune checkpoint inhibitors (ICIs) are revolutionizing cancer treatment but can cause immune-related adverse events (irAEs). This review summarizes irAEs and discusses management strategies for a team-based approach.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Therapeutics

Background:

  • The integration of immunology into oncology has led to the development of immune checkpoint inhibitors (ICIs).
  • ICIs are increasingly utilized as standard cancer treatments.
  • Despite their efficacy, ICIs are associated with diverse immune-related adverse events (irAEs).

Purpose of the Study:

  • To summarize the spectrum of immune-related adverse events (irAEs) associated with immune checkpoint inhibitors (ICIs).
  • To discuss the management strategies for irAEs.
  • To emphasize the need for a collaborative, team-based approach in managing irAEs.

Main Methods:

  • Literature review of immune checkpoint inhibitors and their associated immune-related adverse events.
  • Synthesis of information on the presentation and characteristics of various irAEs.

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  • Discussion of established and emerging management protocols for irAEs.

    • Main Results:

    • Immune checkpoint inhibitors (ICIs) can induce a wide range of immune-related adverse events (irAEs) affecting multiple organ systems.
    • Effective management of irAEs often requires a multidisciplinary team involving oncologists, immunologists, and specialists.
    • Early recognition and prompt intervention are crucial for managing irAEs and optimizing patient outcomes.

    Conclusions:

    • The advent of immune checkpoint inhibitors (ICIs) marks a significant advancement in oncology, necessitating a comprehensive understanding of immune-related adverse events (irAEs).
    • A coordinated, team-based approach is essential for the effective diagnosis and management of diverse irAEs.
    • Further research and clinical guidelines are vital to refine irAE management and enhance patient safety during ICI therapy.