Paraneoplastic systemic sclerosis associated with colorectal carcinoma
Dominik Samotij1, Joanna Maj2, Adam Reich1
1Department of Dermatology, University of Rzeszow, Poland.
Reumatologia
|July 26, 2018
Summary
This case study highlights a rare instance where systemic sclerosis, a rheumatic disorder, presented as a paraneoplastic syndrome in a patient with rectal cancer. The findings suggest a potential link between these conditions, warranting further investigation.
Area of Science:
- Rheumatology
- Oncology
- Gastroenterology
Background:
- Rheumatic disorders can manifest as paraneoplastic syndromes, with dermatomyositis and polymyositis being common examples.
- Systemic sclerosis has a controversial, though slightly increased, association with cancer risk.
- The paraneoplastic potential of systemic sclerosis, particularly with colorectal malignancies, remains underexplored.
Purpose of the Study:
- To report a unique case of rectal adenocarcinoma coexisting with systemic sclerosis.
- To investigate the potential paraneoplastic relationship between these two conditions.
- To contribute to the limited literature on systemic sclerosis and colorectal tumors in a paraneoplastic context.
Main Methods:
- Case report of a 57-year-old male patient.
- Clinical observation of the temporal relationship and progression of both rectal adenocarcinoma and systemic sclerosis.
- Literature review on coexisting systemic sclerosis and colorectal tumors, especially in paraneoplastic settings.
Main Results:
- The patient presented with rectal adenocarcinoma and systemic sclerosis.
- A close temporal relationship and parallel disease course were observed.
- Systemic sclerosis exhibited atypically rapid progression, suggesting a paraneoplastic origin.
Conclusions:
- The findings suggest that systemic sclerosis may have presented as a paraneoplastic syndrome in this patient.
- This case underscores the importance of considering paraneoplastic syndromes in rheumatic disorders.
- Further research is needed to elucidate the link between systemic sclerosis and colorectal cancer, particularly in the paraneoplastic setting.
Related Concept Videos
01:18Second Order systems II
411
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
411
01:21First Order Systems
433
First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
433
01:20Second Order systems I
603
A servo system exemplifies a second-order system, featuring a proportional controller and load elements that ensure the output position aligns with the input position. The relationship between these components is described by a second-order differential equation. Applying the Laplace transform under zero initial conditions yields the transfer function, showing how inputs are converted to outputs in the system.
By reinterpreting the system, one can derive the closed-loop transfer function, which...
By reinterpreting the system, one can derive the closed-loop transfer function, which...
603
01:06Thermodynamic Systems
8.2K
A thermodynamic system is a set of objects whose thermodynamic properties are of interest. The system is considered to be embedded in its surroundings or the environment. The system and its environment can exchange heat and do work on each other through a boundary that separates them. However, the immediate surroundings of the system interact with it directly and therefore have a much stronger influence on its behavior and properties.
Consider an example of tea boiling in a kettle. The...
Consider an example of tea boiling in a kettle. The...
8.2K
01:26Classification of Systems-I
596
Linearity is a system property characterized by a direct input-output relationship, combining homogeneity and additivity.
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
596
01:31Classification of Systems-II
509
Continuous-time systems have continuous input and output signals, with time measured continuously. These systems are generally defined by differential or algebraic equations. For instance, in an RC circuit, the relationship between input and output voltage is expressed through a differential equation derived from Ohm's law and the capacitor relation,
509