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Updated: Feb 7, 2026

Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins
Published on: January 6, 2017
Supramolecular helical nanostructures from self-assembly of coil-rod-coil amphiphilic molecules incorporating the
Shengsheng Yu1, Rui Sun1, Tie Chen1
1Key Laboratory for Organism Resources of the Changbai Mountain and Functional Molecules, and Department of Chemistry, College of Science, Yanbian University, No. 977 Gongyuan Road, Yanji 133002, People's Republic of China. lyjin@ybu.edu.cn.
Abstract:
Coil-rod-coil amphipathic oligomers composed of a rigid dianthranide unit and a hydrophilic branched oligoether as the coil segment were synthesized. These amphiphilic molecules self-assemble into clew-like aggregates composed of fibres or helical nanofibers in aqueous solution. Subsequently, supramolecular polymers were produced from the above objects through charge-transfer interactions by adding 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (4F-TCNQ). Interestingly, temperature-sensitive supramolecular chirality was induced by lateral methyl units located at the interface of the rigid and flexible segments. However, upon addition of the electron-acceptor molecule, 4F-TCNQ, strong donor-acceptor interactions restrict any change in supramolecular chirality with temperature.
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