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Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
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Does idiopathic hypercalciuria affect bone metabolism during childhood? A prospective case-control study

Maria Pavlou1, Vasileios Giapros2, Anna Challa1

  • 1Department of Pediatrics, University Hospital of Ioannina, Stavros Niarchos Avenue, 45500, Ioannina, Greece.

Pediatric Nephrology (Berlin, Germany)
|July 26, 2018
PubMed

Insights

Idiopathic hypercalciuria in children shows normal bone formation but increased bone resorption. Dietary changes may help reduce bone resorption markers.

Area of Science:

  • Pediatric Nephrology
  • Pediatric Endocrinology
  • Bone Metabolism

Background:

  • Idiopathic hypercalciuria (IH) in children lacks extensive research on bone metabolism markers.
  • Adult IH is associated with osteopenia, suggesting potential bone health implications in children.
  • The osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kB ligand (sRANKL) system's role in pediatric IH is understudied.

Purpose of the Study:

  • To investigate biochemical markers of bone formation and resorption in children with IH.
  • To evaluate the OPG/sRANKL system in children with IH.
  • To assess the impact of a 3-month dietary intervention on these markers.

Main Methods:

  • Prospective study of 50 children with IH and 50 healthy controls.
  • Measurement of bone formation markers (total ALP, osteocalcin), bone resorption markers (β-Crosslaps), and OPG/sRANKL levels.
  • Dietary recommendations for IH followed for 3 months, with pre- and post-intervention measurements.

Main Results:

  • No significant differences in bone formation markers or OPG/sRANKL between groups.
  • Children with IH exhibited higher β-Crosslaps and β-Crosslaps/osteocalcin ratio at diagnosis.
  • A trend towards decreased β-Crosslaps and reduced 24-h urinary calcium was observed after dietary intervention.

Conclusions:

  • Pediatric IH is associated with normal bone formation but elevated bone resorption.
  • Dietary intervention shows a potential beneficial effect on reducing bone resorption markers.
  • Further research is warranted to understand long-term bone health in children with IH.
Abstract

Keywords:
ChildrenIdiopathic hypercalcuriaOsteocalcinOsteoprotegerinsRANKLβ-Crosslaps

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