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Phlegmonous appendicitis in children is characterized by eosinophilia in white blood cell counts

Maximiliane I Minderjahn1, Dag Schädlich1, Josephine Radtke1

  • 1Department of Pediatric Surgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

World Journal of Pediatrics : WJP
|July 26, 2018
PubMed

Insights

Phlegmonous appendicitis shows higher eosinophil and basophil counts than complicated appendicitis. This difference in white blood cell (WBC) counts may indicate distinct immunological mechanisms and guide future genetic research.

Area of Science:

  • Pediatric Surgery
  • Immunology
  • Inflammatory Diseases

Background:

  • Phlegmonous and complicated appendicitis are distinct entities influenced by hereditary immunological mechanisms.
  • Current clinical methods cannot differentiate between uncomplicated phlegmonous and complicated appendicitis.
  • Distinguishing these appendicitis forms is crucial as treatment strategies differ.

Purpose of the Study:

  • To investigate differences in white blood cell (WBC) counts between phlegmonous and complicated appendicitis.
  • To identify potential biomarkers for differentiating appendicitis types.
  • To provide a basis for future molecular and genetic studies.

Main Methods:

  • Analysis of white blood cell (WBC) counts, including specific subpopulations.
  • Retrospective study of 647 children aged 7–14 years who underwent appendectomy.
  • Data collected from January 2008 to June 2016.

Main Results:

  • Significant eosinophilia and basophilia were observed in phlegmonous appendicitis compared to complicated appendicitis.
  • Eosinophil counts: 0.11 ± 0.19 × 10^9/L in phlegmonous vs. 0.046 ± 0.104 × 10^9/L in complicated (P < 0.0001).
  • Basophil counts: 0.033 ± 0.031 × 10^9/L in phlegmonous vs. 0.028 ± 0.024 × 10^9/L in complicated (P < 0.001).

Conclusions:

  • Phlegmonous appendicitis appears to be primarily driven by eosinophil inflammation, distinct from complicated appendicitis.
  • These findings suggest underlying genetic predispositions influencing appendicitis pathogenesis.
  • The observed differences in WBC counts are stable over time, offering a promising avenue for further research.
Abstract

Keywords:
AppendicitisChildrenEosinophil granulocytesImmunology

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