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Updated: Feb 7, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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Blocking LINC00152 suppresses glioblastoma malignancy by impairing mesenchymal phenotype through the

Jinquan Cai1,2, Jinwei Zhang1,2, Pengfei Wu1,2

  • 1Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, No.246, Xuefu Road, Nangang District, Harbin, 150086, China.

Journal of Neuro-Oncology
|July 26, 2018
PubMed
Abstract

Insights

Long non-coding RNA LINC00152 promotes glioblastoma growth and invasion. Blocking LINC00152 suppresses tumor progression via the miR-612/AKT2/NF-κB pathway, indicating its prognostic value.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioblastoma is a deadly primary brain tumor with poor outcomes.
  • The role of long non-coding RNAs (lncRNAs) in glioblastoma oncogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the role of lncRNA LINC00152 in glioblastoma.
  • To explore its clinical significance and underlying molecular mechanisms.

Main Methods:

  • Bioinformatic analysis of public databases to identify LINC00152.
  • In vitro assays (CCK-8, transwell, colony formation, wound healing) to assess malignant behaviors.
  • In vivo studies using a nude mouse intracranial model and molecular techniques (PCR, Western blot, immunofluorescence, reporter assays) to verify mechanisms.

Main Results:

  • LINC00152 expression correlates with glioma WHO classification and predicts poor glioblastoma prognosis.
  • Inhibition of LINC00152 suppressed glioblastoma growth and invasion both in vitro and in vivo.
  • LINC00152 promotes glioblastoma progression and epithelial-mesenchymal transition via the miR-612-dependent AKT2/NF-κB pathway.

Conclusions:

  • LINC00152 functions as an oncogene in glioblastoma.
  • LINC00152 holds prognostic value for glioblastoma patients.
  • The LINC00152/miR-612/AKT2/NF-κB axis is crucial for glioblastoma pathogenesis.
Keywords:
GlioblastomaLINC00152MiR-612NF-κBProneural–mesenchymal transition

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