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Cancer-targeted delivery systems based on peptides

Theodora Chatzisideri1, George Leonidis1, Vasiliki Sarli1

  • 1Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.

Future Medicinal Chemistry
|July 26, 2018
PubMed

Insights

Peptides are emerging as novel cancer-targeted delivery systems for drugs and diagnostics. This review analyzes recent advances in using peptides to carry cytotoxic drugs or radiometals for cancer therapy.

Area of Science:

  • Oncology
  • Drug Delivery
  • Biotechnology

Background:

  • Growing interest in novel cancer-targeted delivery systems for improved drug delivery and diagnosis.
  • Peptides like bombesin, neurotensin, and octreotide are being explored for their targeting capabilities.
  • Existing peptide-based systems are utilized for therapeutic and diagnostic purposes in clinics.

Purpose of the Study:

  • To provide a synopsis of bibliographic data on various peptides for cancer targeting.
  • To analyze recent advances in the development of peptides as carriers for cytotoxic drugs and radiometals.
  • To highlight the clinical applications of peptide-based drug delivery systems.

Main Methods:

  • Bibliographic data review and analysis.
  • Examination of peptides utilized as carriers for cytotoxic agents (e.g., doxorubicin, paclitaxel) and diagnostic agents (e.g., radioisotopes, dyes).
  • Focus on recent developments in peptide-based drug and radiometal delivery systems.

Main Results:

  • Several peptides, including bombesin and octreotide, have demonstrated potential in clinical settings.
  • Peptides serve as effective carriers for established chemotherapeutic agents and diagnostic payloads.
  • Ongoing research focuses on enhancing the efficacy and specificity of peptide-drug conjugates.

Conclusions:

  • Peptides represent a promising platform for targeted cancer therapy and diagnosis.
  • The development of peptide-based delivery systems is advancing rapidly.
  • Further research is warranted to optimize peptide carriers for enhanced therapeutic outcomes.
Keywords:
ErbB receptor-targeted delivery systemsLHRH receptor-targeted delivery systemsbombesin receptor-targeted delivery systemscancer-targeted drug deliveryintegrin receptor-targeted delivery systemsneurotensin receptor-targeted delivery systemspeptidepeptide-drug conjugatessomatostatin receptor-targeted delivery systems

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