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Updated: Feb 7, 2026

Listeria monocytogenes Infection of the Brain
Published on: October 2, 2018
Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress
John C Flickinger1, Ulrich Rodeck2, Adam E Snook3
1Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA. John.Flickinger@jefferson.edu.
Abstract:
Listeria monocytogenes, a Gram-positive facultative anaerobic bacterium, is becoming a popular vector for cancer immunotherapy. Indeed, multiple vaccines have been developed utilizing modified Listeria as a tool for generating immune responses against a variety of cancers. Moreover, over a dozen clinical trials testing Listeria cancer vaccines are currently underway, which will help to understand the utility of Listeria vaccines in cancer immunotherapy. This review aims to summarize current views on how Listeria-based vaccines induce potent antitumor immunity and the current state of Listeria-based cancer vaccines in clinical trials.
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