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Updated: Feb 7, 2026

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
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An Osteochondral Allograft in a Patient with Ochronosis: A Case Report
Vanna Rocchi1, Bennett Shapiro2, M Robson Fraser3
1Department of Orthopaedic Surgery, Naval Medical Center San Diego, San Diego, California.
Case:
When a 31-year-old man with no prior medical history underwent diagnostic arthroscopy for posttraumatic knee pain, ochronotic arthropathy was identified. Subsequent blood tests led to the diagnosis of alkaptonuria. After a discussion regarding his future military career and prognosis, he elected to proceed with osteochondral allograft transplantation surgery (OATS). He was able to return to active-duty service with minimal knee pain. At the 32-month postoperative visit, he had functional, pain-free motion and an excellent Hospital for Special Surgery (HSS) knee score.
Conclusion:
Alkaptonuria is an uncommon metabolic disorder that causes arthropathy of peripheral joints. When there is a focal defect, an osteochondral allograft is a valid, joint-preserving option that allows return to activity.
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