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Neonatal hepatitis and alpha-1-antitrypsin deficiency. The prognosis in five patients

M Hirschberger, G B Stickler

    Mayo Clinic Proceedings
    |April 1, 1977
    PubMed

    Insights

    Alpha-1 antitrypsin deficiency (PiZ) in infants presenting with neonatal hepatitis may not lead to severe liver disease. Some patients show mild or no symptoms, challenging previous assumptions about prognosis.

    Area of Science:

    • Hepatology
    • Genetics
    • Pediatrics

    Background:

    • Alpha-1 antitrypsin deficiency (PiZ) is a genetic disorder.
    • Neonatal hepatitis is a common presentation in infants with PiZ.

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