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Montelukast and budesonide combination for children with chronic cough-variant asthma

Xiu-Ping Wang1, Lin-Dong Yang, Jin-Fang Zhou

  • 1Department of Paediatrics, Yan'an People's Hospital, Yanan, China.

Medicine
|July 26, 2018
PubMed

Insights

Montelukast combined budesonide (MCB) significantly improved lung function and clinical scores in children with chronic cough-variant asthma (CCVA). MCB demonstrated superior effectiveness compared to budesonide alone, with no serious adverse events reported.

Area of Science:

  • Pediatric Pulmonology
  • Pharmacology
  • Asthma Research

Background:

  • Chronic cough-variant asthma (CCVA) in children presents a diagnostic and therapeutic challenge.
  • Current treatments focus on improving lung function and symptom control.

Purpose of the Study:

  • To evaluate the effectiveness and safety of montelukast combined budesonide (MCB) versus budesonide alone in treating pediatric CCVA.
  • To compare the impact of MCB on lung function and clinical assessment scores.

Main Methods:

  • A study involving 82 children (aged 4-11) with CCVA treated for 8 weeks.
  • Comparison between montelukast combined budesonide (MCB) and budesonide monotherapy.
  • Primary outcomes: lung function (PEFR, FEV1); Secondary outcome: clinical assessment score; Safety: adverse events.

Main Results:

  • MCB significantly improved peak expiratory flow rates (PEFR) and forced expiratory volume in 1 second (FEV1) compared to budesonide alone (P<.02).
  • Clinical assessment scores were significantly better in the MCB group (P<.05).
  • No serious adverse events were observed in either treatment group.

Conclusions:

  • Montelukast combined budesonide (MCB) is more effective than budesonide monotherapy for pediatric CCVA.
  • MCB offers a safe and superior treatment option for improving lung function and clinical outcomes in children with CCVA.

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