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Updated: Feb 7, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
A case report of extranodal NK/T-cell lymphoma in patient with chronic lymphocytic leukemia
Hangping Ge1, Xiangping Wu, Jianping Shen
1Department of Hematology Department of Pathology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Rationale:
Chronic lymphocytic leukemia often results in secondary tumors, the most common being large B cell lymphoma known as Richter syndrome, followed by extranodal NK/T-cell lymphoma (nasal type) is extremely rare.
Patient Concerns:
A chronic lymphocytic leukemia patient presented with nasal congestion.
Diagnoses:
Nasal endoscopy identified a left nasal mass, and the pathology suggested extranodal NK/T-cell lymphoma (nasal type).
Interventions:
The patient received a course of chemotherapy.
Outcomes:
Pneumonia and coagulopathy occurred after chemotherapy, and the patient died shortly thereafter.
Lessons:
It is essential to recognize the transformation of disease earlier in chronic lymphoblastic leukemia patient.
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