Toddler With Intermittent Abnormal Behavior: Is It Isoniazid-Induced Psychosis?

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Indar Kumar Sharawat1, Lesa Dawman2

  • 1From the Department of Paediatrics, VMMC & Safdarjung Hospital.

Pediatric Emergency Care
|July 26, 2018
PubMed

Insights

A 3-year-old child experienced drug-induced psychosis from isoniazid, a tuberculosis medication. Symptoms resolved after discontinuing the drug, highlighting potential adverse effects in young children.

Area of Science:

  • Pediatric Neurology
  • Pharmacology
  • Psychiatry

Background:

  • Psychosis is uncommon in preschool-aged children.
  • Isoniazid is a standard treatment for tuberculosis (TB) and prophylaxis.
  • While overdose can cause psychosis, it's rare at recommended doses.

Observation:

  • A 3-year-old child presented with intermittent abnormal behavior.
  • The behavioral changes began after isoniazid intake.
  • Symptoms persisted for two weeks.

Findings:

  • The child's condition was diagnosed as drug-induced psychosis.
  • Isoniazid was identified as the causative agent.
  • Discontinuation of isoniazid led to symptom resolution.

Implications:

  • This case highlights the potential for isoniazid to induce psychosis even at recommended doses in young children.
  • Clinicians should consider drug-induced psychosis in preschool children with unexplained behavioral changes, especially after starting new medications.
  • Early recognition and drug withdrawal are crucial for recovery.

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