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Combined dietary-exercise intervention for gestational weight gain and birthweight: a meta-analysis
Paul N Morison1, Montserrat Bacardi-Gascon1, Manuel Lopez-Corrales1
1Autonomous University of Baja California, Medical and Psychology School, Calzada Universidad, Parque Industrial Internacional Tijuana, Baja California, México.
Insights
Intensive diet and exercise interventions effectively reduce excessive gestational weight gain and the risk of large for gestational age newborns. This finding supports enhanced prenatal care strategies for improved maternal and infant outcomes.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Public Health Nutrition
Background:
- Excessive gestational weight gain is linked to adverse perinatal outcomes, including large for gestational age (LGA) newborns.
- Effective interventions are needed to manage gestational weight gain and mitigate associated risks.
Purpose of the Study:
- To systematically review and meta-analyze the impact of intensive diet and exercise interventions on gestational weight gain.
- To assess the effect of these interventions on the incidence of large for gestational age newborns.
Main Methods:
- A systematic literature search was conducted on PubMed and the Cochrane database.
- Ten clinical trials were included, analyzed using a random-effect model and sensitivity analysis.
- Quality of evidence was assessed using the GRADE method.
Main Results:
- Intensive interventions significantly reduced gestational weight gain compared to standard prenatal care (p<0.00001) with moderate evidence quality.
- A significant decrease in large for gestational age newborns was observed (p=0.03) with moderate evidence quality.
Conclusions:
- Intensive diet and exercise interventions are effective in reducing both gestational weight gain and the incidence of large for gestational age newborns.
- These findings support the implementation of structured lifestyle interventions in prenatal care.
Background And Objectives:
Excessive gestational weight gain has been associated with higher risk for large for gestational age newborns. This systematic review and meta-analysis aims to assess whether an intensive diet and exercise intervention has an effect in reducing gestational weight gain and large for gestational age newborns.
Methods And Study Design:
The search was conducted on PubMed and Cochrane database. Through PRISMA flow diagram, clinical trials which met the inclusion criteria were selected. Risk of bias, sensitivity analysis, and quality of evidence assessment were conducted using adequate statistical tests, and the quality of evidence was performed by GRADE method. A random-effect model was used to estimate the statistical significance of the meta- analysis.
Results:
Ten clinical trials met the inclusion criteria. Using the random-effect model and a sensitivity analysis, it was found that an intensive patient-centered intervention reduced gestational weight gain when compared with standard prenatal care (Z=6.21 (p<0.00001); Tau²=0.00; Chi²=3.90, df=4 (p=0.42); I²=0%), and the quality of evidence was moderate. An intensive diet and exercise intervention decreased the number of large for gestational age newborns (Z=2.20 (p=0.03); Tau²=0.14; Chi²=7.84, df=4 (p=0.10); I²=49%), and the quality of evidence using the GRADE approach was moderate.
Conclusion:
The present review and meta-analysis indicates that an intensive diet and exercise intervention reduced gestational weight gain and large for gestational age newborns.
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