Related Experiment Video

Updated: Feb 7, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

13.0K

Critical role of FOXO3a in carcinogenesis

Ying Liu1, Xiang Ao1, Wei Ding2

  • 1Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao, 266021, China.

Molecular Cancer
|July 27, 2018
PubMed

Insights

Forkhead box O3 (FOXO3a) functions as a tumor suppressor, inhibiting cancer cell proliferation and invasiveness. Its inactivation is linked to cancer initiation and progression, presenting therapeutic challenges.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • FOXO3a, a transcription factor, regulates crucial cellular processes like apoptosis and proliferation.
  • Its activity is modulated by microRNAs, post-translational modifications, and protein interactions.
  • FOXO3a is implicated in various cancers, including breast, liver, and prostate malignancies.

Purpose of the Study:

  • To review the multifaceted role of FOXO3a in cancer development and progression.
  • To highlight FOXO3a's function as a tumor suppressor.
  • To discuss the challenges in developing FOXO3a-targeted cancer therapies.

Main Methods:

  • Literature review of recent findings on FOXO3a in cancer.
  • Analysis of FOXO3a's regulatory mechanisms (miRNAs, PTMs, protein interactions).
  • Examination of experimental studies on FOXO3a overexpression and silencing in cancer cells.

Main Results:

  • FOXO3a acts as a tumor suppressor, inhibiting cancer cell proliferation, tumorigenesis, and invasiveness.
  • Inactivation of FOXO3a through gene mutation or cytoplasmic sequestration is common in cancer.
  • FOXO3a inactivation correlates with cancer initiation and progression.

Conclusions:

  • FOXO3a plays a critical role in suppressing tumor development.
  • Understanding FOXO3a's complex regulation is key to cancer therapy.
  • Targeting FOXO3a presents a promising, yet challenging, therapeutic strategy for various cancers.
Keywords:
CancerFOXO3aInactivationPost-translational modificationsTumor suppressor

More Related Videos

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia08:38

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

Published on: August 28, 2013

26.1K
Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients06:28

Endotoxin Activity Assay for the Detection of Whole Blood Endotoxemia in Critically Ill Patients

Published on: June 24, 2019

9.9K

Related Concept Videos

Critical Region, Critical Values and Significance Level01:16

Critical Region, Critical Values and Significance Level

The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in  probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
13.4K
Critical Values01:31

Critical Values

A critical value is a definite value obtained from a particular probability distribution at a predecided confidence level (or a predecided significance level) for a given population parameter. The critical value provides demarcation that separates the sample statistics that are likely to occur from the ones that are unlikely to occur based on the given probability distribution and the population parameter to be estimated. The critical value for normal distribution is obtained from the z...
10.4K
Critical Thinking I01:24

Critical Thinking I

Critical thinking helps decision-making and allows nurses to recognize barriers to success and find solutions to possible issues. It helps to brainstorm and implement ideas to achieve goals. Critical thinking helps acknowledge and state workflow inefficiencies while improving management techniques. Nurses understand the value of critical thinking and look for fellow nurses with critical thinking skills to upgrade their professional standards. Critical thinking can advance a nurse's career...
5.2K
Critical Thinking II01:25

Critical Thinking II

Critical thinking is a cognitive process with several attributes. The attributes of critical thinking include the following:
4.7K
Critical Thinking01:19

Critical Thinking

Critical thinking involves reflective and productive thinking and the evaluation of evidence. Critical thinkers seek to understand the deeper meaning of ideas, question assumptions, and make independent decisions about what to believe or do. Scientists, for instance, are often critical thinkers. Critical thinking also requires humility about what we know and don't know and the motivation to look beyond the obvious. It is essential for effective problem-solving.
Colleges and universities are...
1.2K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
376