Imaging evaluation of sorafenib for treatment of advanced hepatocellular carcinoma
Tianying Zheng1, Hanyu Jiang1, Yi Wei1
1Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, China.
Abstract:
Sorafenib, which is a novel targeted agent, plays an important role in treating advanced hepatocellular carcinoma (HCC) through its antiangiogenic and antiproliferative effects. However, conventional morphology-based radiographic evaluation systems may underestimate the efficacy of sorafenib in HCC due to a lack of apparent tumor shrinkage or altered tumor morphology in many cases. This calls for the development of more accurate imaging methods for evaluating sorafenib. The introduction of tumor burden measurements based on viability and other evolving imaging approaches for assessing therapeutic effects are promising for overcoming some of the limitations of the morphology-based criteria. In this review, we summarize various imaging methods that are used to assess treatment responses of advanced HCC to sorafenib. Imaging markers predictive of prognosis in advanced HCC after treatment with sorafenib are also included and discussed.
Insights
Sorafenib effectively treats advanced hepatocellular carcinoma (HCC) but requires advanced imaging beyond standard methods to accurately assess treatment response and patient prognosis. New imaging markers are crucial for evaluating sorafenib efficacy in HCC.
Area of Science:
- Hepatobiliary Medicine
- Radiology
- Oncology
Background:
- Sorafenib is a targeted therapy for advanced hepatocellular carcinoma (HCC), acting via antiangiogenic and antiproliferative mechanisms.
- Conventional radiographic evaluations may not accurately reflect sorafenib's efficacy in HCC due to limited changes in tumor morphology.
- There is a need for improved imaging techniques to assess treatment response to sorafenib in advanced HCC.
Purpose of the Study:
- To review current and emerging imaging methods for evaluating sorafenib treatment response in advanced HCC.
- To discuss imaging markers that predict prognosis in advanced HCC patients treated with sorafenib.
Main Methods:
- Literature review of imaging modalities used for HCC treatment assessment.
- Focus on methods evaluating sorafenib's therapeutic effects beyond morphology.
- Inclusion of prognostic imaging markers.
Main Results:
- Morphology-based assessments often underestimate sorafenib efficacy in HCC.
- Tumor burden measurements and viability-based imaging show promise.
- Various imaging techniques and prognostic markers are discussed.
Conclusions:
- Advanced imaging is essential for accurate assessment of sorafenib treatment in HCC.
- Evolving imaging approaches can overcome limitations of traditional methods.
- Identifying predictive imaging markers can guide patient management and prognosis.
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