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Electroacupuncture Improves Intestinal Dysfunction in Septic Patients: A Randomised Controlled Trial.

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Electroacupuncture (EA) at ST36-ST37 significantly reduced inflammatory markers and improved intestinal function in sepsis patients. This treatment offers protective effects for intestinal dysfunction, a common complication of sepsis.

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Area of Science:

  • Integrative Medicine
  • Gastroenterology
  • Critical Care Medicine

Background:

  • Sepsis-induced intestinal dysfunction is a critical condition associated with high morbidity and mortality.
  • The "syndrome of obstruction of the bowels Qi" is a Traditional Chinese Medicine (TCM) pattern observed in sepsis-induced intestinal dysfunction.
  • Conventional therapies for sepsis-induced intestinal dysfunction have limitations in fully restoring intestinal function.

Purpose of the Study:

  • To evaluate the efficacy of electroacupuncture (EA) at Zusanli (ST36) and Shangjuxu (ST37) in managing sepsis-induced intestinal dysfunction.
  • To assess EA's impact on reducing inflammatory responses and improving intestinal barrier function.
  • To investigate EA's effects on TCM-defined intestinal dysfunction patterns in sepsis patients.

Main Methods:

  • A randomized controlled trial involving 71 patients with sepsis-induced intestinal dysfunction.
  • The treatment group received EA at ST36-ST37 twice daily for five days, in addition to conventional therapies.
  • The control group received only conventional therapies.
  • Key biomarkers including procalcitonin (PCT), tumor necrosis factor-α (TNF-α), intestinal fatty acid-binding proteins (I-FABP), D-lactate, and citrulline were measured, alongside TCM quantitative scores for intestinal dysfunction.

Main Results:

  • EA treatment significantly reduced plasma levels of PCT, TNF-α, I-FABP, and D-lactate compared to the control group (P<0.05).
  • EA significantly increased plasma citrulline levels, indicating improved intestinal function (P<0.05).
  • The TCM quantitative score for intestinal dysfunction also showed a significant decline in the EA group (P<0.05).
  • No significant differences were observed in mechanical ventilation duration, ICU length of stay, or 28-day mortality between the groups.

Conclusions:

  • Electroacupuncture at ST36-ST37 demonstrates significant efficacy in mitigating inflammatory reactions associated with sepsis-induced intestinal dysfunction.
  • EA provides protective effects on intestinal function and barrier integrity in patients with this condition.
  • EA may serve as a valuable adjunctive therapy for sepsis-induced intestinal dysfunction, particularly for the "syndrome of obstruction of the bowels Qi."