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The coagulation system in host defense

Silvio Antoniak1

  • 1Program in Thrombosis and Hemostasis Department of Pathology and Laboratory Medicine University of North Carolina at Chapel Hill Chapel Hill NC USA.

Research and Practice in Thrombosis and Haemostasis
|July 27, 2018
PubMed

The blood coagulation system and immune system of higher organisms are thought to have a common ancestral origin. During infections, the blood coagulation system is activated and components of the hemostatic system are directly involved in the immune response and immune system modulations. The current view is that the activation of coagulation is beneficial for infections with bacteria and viruses. It limits pathogen dissemination and supports pathogen killing and tissue repair. On the other hand, over-activation can lead to thrombosis with subsequent depletion of hemostatic factors and secondary bleeding. This review will summarize the current knowledge on blood coagulation and pathogen infection with focus on most recent studies of the role of the different parts of the blood coagulation system in selected bacterial and viral infections.

Keywords:
coagulationhemostasisinfectioninflammationperitonitispneumonia

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