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Half-dose versus full-dose macrocyclic gadolinium at 3-T magnetic resonance imaging in paediatric bone and

Giovanna Stefania Colafati1, Enrica Rossi2, Chiara Carducci3

  • 1Department of Imaging, Neuroradiology Unit, Bambino Gesù Children's Hospital, Piazza Sant'Onofrio 4, 00165, Rome, Italy. gstefania.colafati@opbg.net.

Pediatric Radiology
|July 27, 2018
PubMed
Abstract

Insights

Reducing gadolinium-based contrast agent dose in pediatric MRI is feasible. Halving the dose of gadoterate meglumine in 3-Tesla MRI for bone and soft-tissue diseases maintained diagnostic image quality.

Area of Science:

  • Radiology
  • Pediatric Imaging
  • Magnetic Resonance Imaging

Background:

  • Growing concerns regarding gadolinium-based contrast agent safety necessitate dose reduction strategies.
  • Investigating methods to minimize gadolinium exposure in pediatric patients is crucial.

Purpose of the Study:

  • To evaluate the efficacy of a reduced gadolinium dose in pediatric MRI.
  • Compare half-dose versus standard full-dose gadoterate meglumine at 3-Tesla MRI for bone and soft-tissue pathologies.

Main Methods:

  • Prospective enrollment of 45 pediatric patients with bone and soft-tissue diseases.
  • Administration of two consecutive half-doses (0.05 mmol/kg) of gadoterate meglumine during 3-T MRI.
  • Qualitative assessment of diagnostic image quality and quantitative analysis of signal-to-noise and contrast-to-noise ratios.

Main Results:

  • No significant difference in signal-to-noise ratio and contrast-to-noise ratio between half-dose and full-dose groups.
  • Excellent diagnostic image quality was achieved with both dosing regimens.
  • High inter-reader agreement (Cohen κ=0.8) for qualitative image assessment.

Conclusions:

  • Halving the standard dose of gadoterate meglumine is feasible in pediatric 3-T MRI.
  • Reduced gadolinium dosage can be employed for bone and soft-tissue imaging without compromising diagnostic quality.
  • This strategy offers a potential approach to enhance patient safety in pediatric MRI.
Keywords:
3-TChildrenContrast agentContrast-to-noise ratioDoseGadoliniumGadoterate meglumineMagnetic resonance imagingSignal-to-noise ratio

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