Cytogenetics of a renal adenocarcinoma in a 2-year-old child

Chromosomal abnormalities in a 2.4-year-old boy with renal adenocarcinoma (Grawitz tumor) are described. Renal adenocarcinoma is extremely rare in childhood, compared with nephroblastoma (Wilms' tumor). In all tumor cells the same 46,XY,t(X;1) (p11.2;q21.2) karyotype was found. This karyotype is compared with the cytogenetic descriptions of renal adenocarcinoma in adults.