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Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer

Kaumudi Bhawe1, Deodutta Roy2

  • 1Department of Environmental Health Sciences, Florida International University, Miami, FL, 33199, USA.

Cellular Oncology (Dordrecht, Netherlands)
|July 27, 2018
PubMed
Abstract

Insights

Nuclear respiratory factor 1 (NRF1) interacts with E2F4 and MYC to regulate genes crucial for cancer development. This interplay influences key cancer hallmarks, offering new therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Nuclear respiratory factor 1 (NRF1) is a multifunctional protein beyond mitochondrial biogenesis.
  • Emerging data link NRF1 to cancer development and progression.
  • NRF1's novel roles involve interactions with transcription factors E2F4 and MYC.

Purpose of the Study:

  • To identify common target genes regulated by NRF1, E2F4, and MYC.
  • To investigate the role of NRF1 in cancer hallmarks through its interplay with E2F4 and MYC.
  • To explore the potential of NRF1-E2F4-MYC interactions in cancer therapy.

Main Methods:

  • Analysis of Encyclopedia of DNA Elements (ENCODE) NRF1 ChIP-Seq data.
  • Identification of common NRF1, E2F4, and MYC binding motifs in human genes.
  • Bioinformatic analysis of target genes involved in cancer signaling pathways.

Main Results:

  • Identified 9253 common target genes for NRF1, E2F4, and MYC.
  • NRF1 binding motifs are present in genes regulating proliferation, invasion, self-renewal, and apoptosis.
  • NRF1, E2F4, and MYC co-regulate genes involved in multiple cancer hallmarks.

Conclusions:

  • NRF1, alongside E2F4 and MYC, plays a critical role in human cancer development.
  • This tripartite interaction orchestrates common target genes across multiple cancer-related networks.
  • Understanding this interplay is vital for developing novel cancer treatments and predictive biomarkers.
Keywords:
CancerE2F4MYCNuclear respiratory factor 1 (NRF1)

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