Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
Bone Structure01:55

Bone Structure

51.8K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.8K
Bone Remodeling01:40

Bone Remodeling

40.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
Compact Bone01:27

Compact Bone

16.6K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.6K
Bone Disorders01:29

Bone Disorders

5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DOT1L regulates dystrophin expression and is critical for cardiac function.

Genes & development·2011
Same author

The ribosomal intergenic spacer (IGS) region in Schistosoma japonicum: structure and comparisons with related species.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2011
Same author

Effects of intravesical liposome-mediated human beta-defensin-2 gene transfection in a mouse urinary tract infection model.

Microbiology and immunology·2011
Same author

A polyacrylamide microbead-integrated chip for the large-scale manufacture of ready-to-use esiRNA.

Lab on a chip·2011
Same author

Investigation on wide-band scattering of a 2-D target above 1-D randomly rough surface by FDTD method.

Optics express·2011
Same author

A cross-sectional study on posttraumatic impact among Qiang women in Maoxian County 1 year after the Wenchuan Earthquake, China.

Asia-Pacific journal of public health·2011
Same journal

Comprehensive Analysis of Macrophage Dynamics, CCBE1, and Their Implications in Colorectal Cancer Microenvironment: Insights Into Tumor Progression and Therapeutic Opportunities.

Genetics research·2026
Same journal

Compound Heterozygous ATM Variants Cause Adolescent-Onset Cerebellar and Extrapyramidal Disease Without Telangiectasia in a Consanguineous Pakistani Family.

Genetics research·2026
Same journal

Biological Context-Informed and Population-Stratified Strategies Improve Genetic Diagnosis of CCDC22-Related Disorder.

Genetics research·2026
Same journal

Predicting the Impact of Deleterious Single-Nucleotide Polymorphisms in the p47ING1a Isoform of Human ING1 Gene.

Genetics research·2026
Same journal

Two Novel FBN2 Variants Causing Congenital Contractural Arachnodactyly.

Genetics research·2026
Same journal

Identification of Genetic Diagnostic Markers for Systemic Lupus Erythematosus.

Genetics research·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

7.0K

Epigenetics and bone diseases.

Tu Huang1, Xiu Peng2, Zhenxia Li1

  • 1State Key Laboratory of Oral Diseases,Department of Orthodontics,West China School of Stomatology,Sichuan University,Chengdu 610041,PR China.

Genetics Research
|July 27, 2018
PubMed
Summary
This summary is machine-generated.

Epigenetic mechanisms regulate gene expression without altering DNA sequence. This review explores their role in skeletal development, homeostasis, and disease, highlighting future prospects in epigenetics.

More Related Videos

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues
06:16

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

Published on: April 26, 2024

1.3K
ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.3K

Related Experiment Videos

Last Updated: Feb 7, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

7.0K
Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues
06:16

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

Published on: April 26, 2024

1.3K
ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.3K

Area of Science:

  • Genomics
  • Epigenetics
  • Skeletal Biology

Background:

  • The epigenome offers a second dimension for genome analysis, complementing genetic sequencing.
  • Epigenetic mechanisms (DNA methylation, histone modifications, noncoding RNAs) control gene expression without changing the DNA sequence.
  • Aberrant epigenetic patterns are linked to diseases like cancer, age-related conditions, and skeletal disorders.

Purpose of the Study:

  • To review epigenetic mechanisms and their specific involvement in the skeletal system.
  • To elucidate the role of epigenetics in skeletal development, maintenance (homeostasis), and degeneration.
  • To discuss the future directions and potential of epigenetic research in skeletal biology.

Main Methods:

  • Literature review of epigenetic mechanisms.
  • Analysis of epigenetic involvement in skeletal development and disease.
  • Synthesis of current knowledge on epigenetics and the skeletal system.

Main Results:

  • Epigenetic mechanisms are crucial for normal gene regulation in biological processes.
  • Dysregulation of epigenetic patterns contributes to various pathological conditions, including bone and cartilage diseases.
  • Epigenetics plays a significant role throughout the lifespan of the skeletal system.

Conclusions:

  • Epigenetic mechanisms are integral to skeletal biology, influencing development, homeostasis, and degeneration.
  • Understanding these mechanisms offers potential therapeutic targets for skeletal diseases.
  • The field of epigenetics holds significant promise for future advancements in skeletal research and medicine.