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Updated: Apr 3, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
10:27

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells

Published on: March 9, 2012

11.3K

Ras p21 proteins with high or low GTPase activity can efficiently transform NIH/3T3 cells.

J C Lacal, S K Srivastava, P S Anderson

    Cell
    |February 28, 1986
    PubMed
    Summary

    Ras p21 mutants can gain transforming properties without reduced GTPase activity. This study shows efficient transformation can occur through alternative mechanisms, challenging previous assumptions about ras oncogene activation.

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