Related Experiment Video
Updated: Feb 7, 2026
10:11
Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model
Published on: March 7, 2013
15.9K
Haploidentical Donor Bone Marrow Transplantation for Severe Aplastic Anemia
Amy E DeZern1, Robert A Brodsky2
1Division of Hematologic Malignancies, The Johns Hopkins University School of Medicine, 1650 Orleans Street, CRBI Room 3M87, Baltimore, MD 21287-0013, USA.
Hematology/Oncology Clinics of North America
|July 27, 2018
Summary
Hematopoietic stem cell transplantation is the only cure for severe aplastic anemia. HLA haploidentical bone marrow transplantation with post-transplant cyclophosphamide offers a promising alternative for patients lacking matched donors.
Area of Science:
- Hematology
- Immunology
- Transplantation Medicine
Background:
- Severe aplastic anemia (SAA) is a life-threatening condition requiring curative treatment.
- Hematopoietic stem cell transplantation (bone marrow transplantation [BMT]) is the only curative option for SAA.
- Human leukocyte antigen (HLA)-matched sibling BMT is standard for young patients; immunosuppressive therapy is used for others.
Purpose of the Study:
- To provide an overview of the human leukocyte antigen (HLA)-haploidentical BMT approach for severe aplastic anemia (SAA).
- To discuss the evolution and current status of HLA-haploidentical BMT in SAA treatment.
Main Methods:
- Review of current literature and clinical practices regarding HLA-haploidentical BMT in SAA.
- Focus on the role of high-dose post-transplant cyclophosphamide in mitigating graft-versus-host disease.
Main Results:
- Historically, HLA-haploidentical BMT faced challenges with graft rejection and graft-versus-host disease.
- High-dose post-transplant cyclophosphamide has significantly improved outcomes by reducing graft-versus-host disease.
Conclusions:
- HLA-haploidentical BMT is an increasingly utilized approach for SAA patients, particularly those with refractory or relapsed disease.
- Advances like post-transplant cyclophosphamide have made HLA-haploidentical BMT a viable and safer option.
Related Concept Videos
01:22Bone Marrow Sampling and Transplants
1.3K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
1.3K
01:55Bone Structure
51.8K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.8K
01:40Bone Remodeling
40.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.5K
01:27Compact Bone
16.6K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
16.6K
01:29Bone Disorders
5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K
01:12The Hyoid Bone
5.2K
The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
5.2K