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Banking on Polygenicity to Disentangle Psychiatric Comorbidity

Jillian R Haney1, Sepideh Parhami1, Michael J Gandal1

  • 1Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, and the Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|July 27, 2018
PubMed
Summary

No abstract available in PubMed .

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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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