Frontal analysis capillary electrophoresis: recent advances and future perspectives
Edwin F Romano1, Joselito P Quirino1,2
1Department of Chemistry, Negros Oriental State University, Dumaguete City 6200, Philippines.
Bioanalysis
|July 27, 2018
Summary
Frontal analysis capillary electrophoresis (FACE) has advanced for studying molecular interactions, particularly in therapeutic drug development, chemical sensing, and drug delivery systems. Future directions include high-sensitivity detection for clinical diagnostics.
Area of Science:
- Analytical Chemistry
- Biochemistry
- Separation Science
Background:
- Frontal analysis capillary electrophoresis (FACE) is a powerful technique for studying molecular interactions.
- Review covers developments from 2012 to 2017, focusing on applications beyond traditional drug studies.
Purpose of the Study:
- To review advancements in FACE for analyzing simple and complex systems.
- To highlight diverse applications including chemical sensing, drug delivery, and inhibitor screening.
- To discuss new ligand-substrate systems and detection methods.
Main Methods:
- Review of scientific literature published between 2012 and 2017.
- Analysis of studies utilizing FACE for interaction studies.
- Comparison with other analytical techniques for binding interaction analysis.
Main Results:
- Significant focus on therapeutic drug-related studies, alongside applications in chemical sensing and drug delivery.
- Introduction of novel ligand-substrate systems like template-molecularly imprinted polymers.
- Integration of ESI-MS detection in recent studies.
Conclusions:
- FACE is a versatile technique with expanding applications in various scientific fields.
- Future research should prioritize high-sensitivity detection and high-throughput screening for clinical applications.
- FACE shows promise for drug discovery, natural product analysis, and biomarker identification.
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