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Updated: Feb 7, 2026
07:57
A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
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Adiponectin is decreased in bipolar depression.
Martina Platzer1, Frederike T Fellendorf1, Susanne A Bengesser1
1Department of Psychiatry and Psychotherapy, Medical University of Graz, Graz, Austria.
Summary
Low adiponectin levels are associated with depression in women with bipolar disorder (BD). This finding suggests adiponectin may play a role in BD
Area of Science:
- Neuroendocrinology
- Psychiatry
- Metabolic Syndrome
Background:
- Bipolar disorder (BD) frequently co-occurs with medical conditions.
- Adipokines, like adiponectin and leptin, are implicated in metabolic and inflammatory processes.
- Potential links exist between adipokines and core BD symptoms, including mood and cognition.
Purpose of the Study:
- To investigate the association between adiponectin and leptin levels and bipolar disorder.
- To explore the relationship between adipokines and mood status in BD patients.
Main Methods:
- Blood samples were collected from 120 individuals with BD and 68 controls.
- Adiponectin and leptin concentrations were measured.
- Statistical analyses were performed, including controlling for BMI and stratifying by mood status.
Main Results:
- Lower adiponectin levels were observed in female BD patients compared to controls, independent of BMI.
- Significant differences in adiponectin levels were found across control, euthymic BD, and depressive BD groups.
- A significant association was confirmed between reduced adiponectin and depressive states in BD.
Conclusions:
- This study reinforces the link between low adiponectin and depression in bipolar disorder.
- Adiponectin may influence BD pathophysiology and comorbidities through metabolic and inflammatory pathways.
- Further research into adiponectin's role in BD is warranted.
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