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SZSJ protects against insomnia by a decrease in ADMA level and an improvement in DDAH production in sleep-deprived
Hong-Bo Xiao1, Yi-Shan Wang2, Zhi-Feng Luo3
1College of Veterinary Medicine, Hunan Agricultural University, China; Hunan Province University Key Laboratory for Agricultural Biochemistry and Biotransformation, Hunan Agricultural University, China; Hunan Engineering Research Center of Veterinary Drug, China.
Life Sciences
|July 27, 2018
Summary
Jujubosides from Semen Ziziphi Spinosae (SZSJ) improve sleep in rats by increasing dimethylarginine dimethylaminohydrolase (DDAH) and reducing asymmetric dimethylarginine (ADMA) levels, offering a potential treatment for sleep disorders.
Area of Science:
- Neuroscience
- Pharmacology
- Sleep Medicine
Background:
- Sleep disorders are a growing concern.
- Dimethylarginine dimethylaminohydrolase (DDAH) has been implicated in sleep regulation.
- Semen Ziziphi Spinosae (SZSJ) is a traditional herb with potential therapeutic properties.
Purpose of the Study:
- To investigate the hypnotic effect of SZSJ on sleep deprivation in rats.
- To elucidate the underlying mechanisms involving DDAH and asymmetric dimethylarginine (ADMA).
Main Methods:
- Forty rats were divided into four groups: sleep-deprived with SZSJ treatment (10 or 30 mg/kg), sleep-deprived control, and healthy control.
- Measurements included cerebral DDAH expression, ADMA levels, sleep parameters, behavior, and neurotransmitters.
Main Results:
- SZSJ treatment increased DDAH I and DDAH II expression.
- Total sleep time and levels of GABA and 5-HT were elevated.
- Behavioral indicators of distress and levels of 8-isoprostane, ADMA, norepinephrine, and glutamate were reduced.
Conclusions:
- SZSJ demonstrates a protective effect against insomnia in sleep-deprived rats.
- The mechanism involves decreasing ADMA levels and enhancing DDAH production.
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