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Quantitation of NAD+: Why do we need to measure it?
Yue Liu1, James Clement2, Ross Grant3
1Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia.
Background:
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is currently investigated as an important target to extend lifespan and health span. Age-related NAD+ depletion due to the accumulation of oxidative stress is associated with reduced energy production, impaired DNA repair and genomic instability.
Scope Of Review:
NAD+ levels can be elevated therapeutically using NAD+ precursors or through lifestyle modifications including exercise and caloric restriction. However, high amounts of NAD+ may be detrimental in cancer progression and may have deleterious immunogenic roles.
Major Conclusions:
Standardized quantitation of NAD+ and related metabolites may therefore represent an important component of NAD+ therapy.
General Significance:
Quantitation of NAD+ may serve dual roles not only as an ageing biomarker, but also as a diagnostic tool for the prevention of malignant disorders.
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