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Updated: Feb 7, 2026

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
Published on: March 8, 2014
A Monte Carlo study of bone-tissue interface microdosimeters
I-Chun Cho1, Fang-Hsin Chen1, Tsi-Chian Chao1
1Department of Medical Imaging and Radiological Sciences, Chang Gung University, Guishan Dist., Taoyuan City 333, Taiwan; Medical Physics Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital, Guishan Dist., Taoyuan City 333, Taiwan.
Abstract:
Radiation-induced bone diseases were frequently reported in radiotherapy patients. To study the diseases, microdosimeters were constructed with walls of A150-A150, A150-B100, B100-A150 and B100-B100 interfaces. Monte Carlo simulations of these microdosimeters were performed to determine the lineal energy spectra of an interface site at different depths in water for 230 MeV protons. Comparing these spectra with data of ICRU tissue and bone walls, better agreements were found at shallow depths for protons and delta-rays than deep depths for nuclear interactions.
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