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Cochlear Function in Adults with Epilepsy and Treated with Carbamazepine
Sherifa A Hamed1, Amira M Oseilly2
1Department of Neurology and Psychiatry, Assiut University Hospital, Assiut, Egypt.
Audiology & Neuro-Otology
|July 27, 2018
Summary
Long-term epilepsy treatment with carbamazepine (CBZ) may impair hearing. This study found reduced cochlear function in patients taking CBZ, suggesting auditory deficits are a potential side effect.
Area of Science:
- Audiology
- Neurology
- Pharmacology
Background:
- Epilepsy is a chronic neurological disorder often requiring long-term medication.
- Patients with epilepsy may experience various comorbidities, including those related to treatment side effects.
Purpose of the Study:
- To investigate cochlear function in patients with idiopathic epilepsy.
- To assess the impact of carbamazepine (CBZ) treatment on auditory health.
Main Methods:
- Pure-tone audiometry and transient evoked otoacoustic emission (TEOAE) analyses were performed.
- 47 patients with idiopathic epilepsy and 40 healthy controls participated.
Main Results:
- One-third of epilepsy patients reported hearing loss, primarily mild and bilateral.
- Patients exhibited lower TEOAE amplitudes, especially at higher frequencies (3-4 kHz), compared to controls.
- TEOAE amplitudes correlated negatively with CBZ dose, serum levels, and duration of treatment.
Conclusions:
- Long-term carbamazepine treatment is associated with cochlear dysfunction.
- Auditory deficits may be an adverse effect of carbamazepine therapy in epilepsy patients.
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