Related Experiment Video

Updated: Feb 7, 2026

An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

12.1K

[Study of the prevalence of neonatal thyroid disturbances in Benin]

G Yessoufou1, A E Agossou2, F Baba-Moussa3

  • 1Laboratoire de Biomembranes et Signalisation Cellulaire, Département de Physiologie Animale, FAST, Université d'Abomey Calavi, B.P. 526, Cotonou République du Bénin.

Le Mali Medical
|July 28, 2018
PubMed

Insights

Neonatal screening in Cotonou, Benin revealed significant thyroid dysfunction, with 28% of infants exhibiting hypothyroidism. Maternal anti-thyroglobulin antibodies may contribute to this prevalence in newborns.

Area of Science:

  • Endocrinology
  • Neonatal Health
  • Immunology

Context:

  • Neonatal thyroid dysfunction poses a global health concern.
  • Limited data exists on thyroid profiles in West African neonates.
  • Understanding neonatal thyroid status is crucial for early intervention.

Purpose:

  • To determine the prevalence of thyroid dysfunction in neonates in Cotonou, Benin.
  • To analyze the concentrations of free thyroxine (FT4) and thyrotropin (TSH) in newborns.
  • To investigate the role of thyroid antibodies in neonatal thyroid disturbance.

Summary:

  • A study of 177 neonates in Cotonou, Benin, measured FT4, TSH, and thyroid antibodies.
  • Prevalence of thyroid dysfunction was 28% for hypothyroidism and 2.25% for hyperthyroidism.
  • Elevated anti-thyroglobulin antibodies were observed in both hypothyroid and euthyroid neonates, suggesting lymphocytic thyroiditis.

Impact:

  • Highlights a high incidence of neonatal hypothyroidism in the study population.
  • Suggests maternal antibody transfer as a potential cause of neonatal hypothyroidism.
  • Informs public health strategies for neonatal thyroid screening and management in the region.
Abstract

Keywords:
BeninBéninHypothyroidismThyroidThyroïde Hypothyroïdiecongenitalcongénitaleneonatalnéonatales

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K
Probiotic Studies in Neonatal Mice Using Gavage10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

20.8K

Related Concept Videos

Ecological Disturbance02:26

Ecological Disturbance

An ecological disturbance is a temporary disruption in the environment resulting from abiotic, biotic, or anthropogenic factors, causing a pronounced change in an ecosystem. The impact of an ecological disturbance, which can depend on its intensity, frequency, and spatial distribution, plays a significant role in shaping the species diversity within the ecosystem.
21.1K
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.9K
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
3.0K
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.7K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.7K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.9K