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[Endemic Kaposi's sarcoma in Dakar: 29 cases].
Maodo Ndiaye1, Assane Diop2, Siritio Berthé1
1Hôpital Aristide Le Dantec, Service de Dermatologie.
Le Mali Medical
|July 28, 2018
Summary
Endemic Kaposi's sarcoma in sub-Saharan Africa primarily affects the elderly, often presenting with extensive extracutaneous involvement. Treatment with bleomycin showed favorable outcomes in over half of the studied cases.
Area of Science:
- Oncology
- Epidemiology
- Dermatology
Context:
- Limited data exists on endemic Kaposi's sarcoma (KS) in sub-Saharan Africa.
- This study addresses the need for comprehensive data on KS in this region.
Purpose:
- To elucidate the epidemiological, clinical, and therapeutic characteristics of endemic Kaposi's sarcoma in sub-Saharan Africa.
Summary:
- A 7-year retrospective study identified 29 cases of endemic Kaposi's sarcoma.
- The mean age was 63.2 years, with a male-to-female ratio of 2.22.
- Common manifestations included cutaneous lesions (51.72% angiomatous papulonodular), mucosal involvement (24.13%), and extracutaneous lesions (50% bone, lymph nodes, GI, lung).
- Bleomycin chemotherapy resulted in favorable outcomes for over half the patients, with recurrences in 2 cases.
Impact:
- Findings indicate endemic Kaposi's sarcoma is more prevalent in older individuals.
- The study highlights a higher frequency of extracutaneous involvement and aggressive disease forms in this population.
- This research provides crucial insights for understanding and managing Kaposi's sarcoma in sub-Saharan Africa.