Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased water excretion in hyperprolactinemic rats.

R A Adler, V L Herzberg, T Brinck-Johnsen

    Endocrinology
    |April 1, 1986
    PubMed
    Summary

    This study shows that elevated prolactin (PRL) levels in rats increase water excretion, suggesting a direct kidney effect. This finding clarifies prolactin's role in mammalian water balance.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Acute Lower Extremity Fracture Management in Chronic Spinal Cord Injury: 2022 Delphi Consensus Recommendations.

    JB & JS open access·2022
    Same author

    Osteoporosis care amidst the prolonged pandemic.

    Journal of endocrinological investigation·2021
    Same author

    Bone and non-contractile soft tissue changes following open kinetic chain resistance training and testosterone treatment in spinal cord injury: an exploratory study.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
    Same author

    Consensus statement from 2<sup>nd</sup> International Conference on Controversies in Vitamin D.

    Reviews in endocrine & metabolic disorders·2020
    Same author

    Correction to: Hip fracture trends in the United States, 2002 to 2015.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
    Same author

    MANAGEMENT OF ENDOCRINE DISEASE: Therapeutics of Vitamin D.

    European journal of endocrinology·2018

    Area of Science:

    • Endocrinology
    • Renal Physiology
    • Mammalian Physiology

    Background:

    • The function of prolactin (PRL) in regulating mammalian salt and water balance is not fully understood.
    • Previous studies faced challenges with exogenous PRL administration methods.

    Purpose of the Study:

    • To investigate the physiological effects of endogenous hyperprolactinemia on renal function in rats.
    • To elucidate the role of prolactin in mammalian water balance by establishing a reliable model of sustained hyperprolactinemia.

    Main Methods:

    • Induced endogenous hyperprolactinemia in rats by transplanting anterior pituitary glands.
    • Controlled for glucocorticoid secretion via adrenalectomy and corticosterone replacement.
    • Administered 0.9% saline as drinking fluid.
    • Measured urine flow, urine osmolality, and electrolyte excretion.

    Main Results:

    • Pituitary-grafted rats exhibited a significant increase in urine flow compared to controls (38.9 vs. 20.7 ml/24 h/100 g BW).
    • Urine osmolality was reduced in hyperprolactinemic rats, while sodium and potassium excretion remained unchanged.
    • Elevated urine flow persisted even when adjusted for increased fluid intake, indicating a direct effect beyond thirst.

    Conclusions:

    • Hyperprolactinemia in rats leads to increased water excretion, likely mediated by a direct renal effect of prolactin.
    • Glucocorticoid excess or primary changes in thirst do not appear to be the primary drivers of this observed diuresis.
    • Prolactin may influence water absorption in the gut, contributing to the overall diuretic effect.

    Related Experiment Videos