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Updated: Feb 7, 2026
08:00
Studying Brain Function in Children Using Magnetoencephalography
Published on: April 8, 2019
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Parent-reported executive functioning in young children treated for cancer.
Jennifer L Harman1, Andrew E Molnar1, Lauren E Cox1
1a Department of Psychology , St. Jude Children's Research Hospital , Memphis , TN , USA.
Summary
Young children treated for cancer show emerging executive function weaknesses, particularly in working memory. These cognitive challenges impact broader functioning, highlighting early childhood cancer risks.
Area of Science:
- Pediatric Oncology
- Neuropsychology
- Developmental Psychology
Background:
- Children treated for cancer face cognitive and functional impairments.
- Research often focuses on older children, leaving a gap in understanding executive function in preschoolers.
- Early identification of cognitive risks in young cancer patients is crucial.
Purpose of the Study:
- To examine executive functioning in preschool-aged children with cancer.
- To investigate the association between executive function and other functional domains.
- To identify specific executive function weaknesses in this vulnerable population.
Main Methods:
- Retrospective analysis of clinical cognitive evaluation data from 61 young oncology patients.
- Assessment of executive functions, including working memory, in children aged approximately 5 years.
- Correlation analysis with global intelligence, adaptive functioning, and pre-academic skills.
Main Results:
- Significant executive function discrepancies from the mean were observed in most domains.
- Nearly half of preschoolers (47.5%) had clinically significant parent-reported working memory concerns.
- Executive functioning correlated with global intelligence and adaptive functioning.
Conclusions:
- Young children with cancer exhibit emerging executive function deficits.
- These findings underscore the cognitive and behavioral risks associated with early childhood cancer diagnoses.
- Further research is needed to support early-identified cognitive and functional impairments.
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