Related Experiment Video

Updated: Feb 7, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers
12:13

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

12.3K

Systematic review on the treatment of deceased organ donors

Anne C van Erp1, Leon F A van Dullemen1, Rutger J Ploeg2

  • 1Department of Surgery, University Medical Centre Groningen, the Netherlands.

Transplantation Reviews (Orlando, Fla.)
|July 28, 2018
PubMed
Abstract

Insights

This systematic review found no evidence that deceased donor treatments improve long-term transplant outcomes. Further research is needed to optimize graft quality and patient survival after organ transplantation.

Area of Science:

  • Transplantation immunology
  • Organ preservation
  • Graft survival optimization

Background:

  • Lack of consensus on standard deceased-donor management protocols.
  • Need to improve graft quality and transplantation outcomes.
  • Importance of evaluating interventions in deceased donors.

Purpose of the Study:

  • Systematically review the effects of deceased-donor treatments on graft function.
  • Evaluate the impact of these treatments on post-transplantation survival.

Main Methods:

  • Systematic search of PubMed, Embase, Cochrane, and Clinicaltrials.gov.
  • Inclusion of randomized controlled trials comparing donor treatments to placebo or no treatment.
  • Meta-analyses conducted on specific treatment strategies.

Main Results:

  • Methylprednisolone in liver donors showed no effect on acute rejection rates.
  • Antidiuretic hormone in kidney donors did not prevent delayed graft function.
  • Ischaemic preconditioning improved short-term liver function but not long-term outcomes.

Conclusions:

  • Insufficient evidence to support any specific deceased-donor treatment for improving long-term graft or patient survival.
  • Further research is required to establish effective donor management strategies.
  • Current interventions lack proven efficacy in enhancing transplant success.
Keywords:
Brain deathDeceased donorManagementOrganSystematic reviewTreatment

More Related Videos

Author Spotlight: Learning Systematic Bronchoscopy in a Simulation-Base Setting04:47

Author Spotlight: Learning Systematic Bronchoscopy in a Simulation-Base Setting

Published on: June 23, 2023

3.6K
Single Port Donor Nephrectomy07:17

Single Port Donor Nephrectomy

Published on: March 12, 2011

52.4K

Related Concept Videos

Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.5K
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.1K
Systematic Sampling Method01:17

Systematic Sampling Method

Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
13.3K
Propagation of Uncertainty from Systematic Error01:10

Propagation of Uncertainty from Systematic Error

The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
1.5K
Systematic Error: Methodological and Sampling Errors01:15

Systematic Error: Methodological and Sampling Errors

In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
11.0K