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Updated: Feb 7, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
Control of Inflammasome Activation by Phosphorylation
Tao Gong1, Wei Jiang2, Rongbin Zhou3
1Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, People's Republic of China.
Abstract:
Inflammasomes are cytosolic protein complexes composed of innate immune sensors, the adaptor protein ASC, and the cysteine protease caspase-1. In response to microbial infection or 'danger signals', inflammasomes play critical roles in host defense or contribute to the pathogenesis of various inflammatory diseases. Recent studies have provided abundant evidence for a vital role of phosphorylation in the regulation of inflammasome assembly and activation. This review integrates previous observations and discoveries for inflammasome regulation by protein phosphorylation with the most recent findings. Additionally, the timely application and clinical prospects in the treatment of inflammatory diseases, by targeting related protein kinases or phosphatases, are also discussed.
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