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Updated: Feb 7, 2026

Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

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Progress in the treatment of solid tumors with apatinib: a systematic review

Deze Zhao1, Helei Hou1, Xiaochun Zhang1

  • 1Department of Medical Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266003, China, zhangxiaochun9670@126.com.

Oncotargets and Therapy
|July 28, 2018
PubMed

Insights

Apatinib, an oral VEGFR-2 inhibitor, shows promise in treating solid tumors by blocking angiogenesis. It improves survival outcomes for patients with manageable side effects.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Vascular Endothelial Growth Factor (VEGF) drives tumor angiogenesis and growth.
  • VEGF and its receptor are overexpressed in many solid tumors, making them therapeutic targets.
  • Targeting molecular pathways has led to successful oncotherapy agents.

Purpose of the Study:

  • To summarize recent research on apatinib, an oral small-molecule tyrosine kinase inhibitor of VEGFR-2.
  • To review apatinib's mechanism of action, pharmacokinetics, clinical trials, and adverse reactions.
  • To discuss the therapeutic prospects of apatinib in cancer treatment.

Main Methods:

  • Review of current studies on apatinib.
  • Analysis of apatinib's mechanism in inhibiting angiogenesis and tumorigenesis.
  • Evaluation of clinical trial data regarding efficacy and safety.

Main Results:

  • Apatinib inhibits VEGFR-2, restraining angiogenesis and tumor growth.
  • It demonstrates promising efficacy as a post-second- and post-third-line treatment for various solid tumors.
  • Apatinib significantly improves overall survival and progression-free survival with tolerable adverse reactions.

Conclusions:

  • Apatinib is a potential therapeutic agent for solid tumors by targeting VEGF signaling.
  • Its ability to improve survival outcomes warrants further investigation and clinical application.
  • Further research into its mechanism, pharmacokinetics, and long-term effects is ongoing.
Keywords:
VEGFVEGFR-2angiogenesisapatinibgastric cancersolid tumors

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