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Published on: December 27, 2024
Vitamin D and its metabolites: from now and beyond
Etienne Cavalier1, Jean-Claude Souberbielle2
1Department of Clinical Chemistry, University of Liege, CHU de Liège, Belgium.
Abstract:
Total 25-hydroxyvitamin D is currently considered as the most representative metabolite of vitamin D status. There are a multitude of challenges that still deserve to be addressed and despite recent technological advances its determination remains complicated. This current review gives an abbreviated overview of the phases of development that vitamin D metabolite determination has gone through and discusses the difficulties that still require resolving. Furthermore, given the different platforms and methodologies available, the critical issue of standardization and all efforts made as far towards its realization have been discussed. And last but not least, the concepts of 'free' and 'bioavailable' vitamin D along with the 'Vitamin D Metabolism Ratio' have been discussed.
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