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Impaired Sensorimotor Integration in Restless Legs Syndrome
Yicong Lin1,2, Yijin Wang3, Shuqin Zhan1,2
1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Frontiers in Neurology
|July 28, 2018
Summary
Restless legs syndrome (RLS) patients exhibit increased leg motor cortex excitability and impaired sensorimotor integration. These disturbances in RLS may stem from the cortical level, impacting neural processing.
Area of Science:
- Neuroscience
- Clinical Neurology
- Sensorimotor Integration
Background:
- Restless legs syndrome (RLS) is a sensorimotor disorder potentially involving altered sensorimotor integration.
- The underlying mechanisms of these sensorimotor changes in RLS remain unclear.
Purpose of the Study:
- To investigate sensorimotor integration in RLS patients.
- Utilize transcranial magnetic stimulation-motor evoked potentials (TMS-MEPs) combined with peripheral electrical stimulation.
Main Methods:
- Compared 14 RLS patients with 12 healthy controls.
- Measured tibial and median H-reflexes, resting motor threshold (RMT) for abductor pollicis brevis (APB) and tibialis anterior (TA).
- Assessed motor evoked potentials (MEPs) conditioned by median and peroneal nerve stimulation at various interstimulus intervals (ISIs).
Main Results:
- No significant differences in RMT or H-reflexes between RLS patients and controls.
- RLS patients showed significantly increased unconditioned MEP amplitudes in the tibialis anterior (TA).
- Long-latency afferent inhibition (LAI) was significantly decreased in RLS patients at 150 and 200 ms median nerve stimulation ISIs.
Conclusions:
- Suggests increased motor cortical excitability in the legs of RLS patients.
- Indicates disturbed sensorimotor integration in RLS, potentially originating at the cortical level.
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