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Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Related Experiment Video

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Combining Behavior and EEG to Study the Effects of Mindfulness Meditation on Episodic Memory

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Pilot Study on Epigenetic Response to A Mind-Body Treatment.

M Cozzolino¹, F Guarino², S Castiglione²

¹Department of Human, Philosophical and Educational Sciences, University of Salerno, Italy.

Translational Medicine @ Unisa

|July 28, 2018

Summary

Mind-body therapies alter DNA methylation patterns. This study found that epigenetic profiles became more uniform after treatment, indicating a biological impact of these interventions on gene expression regulation.

Keywords:

DNA methylation epigenetics mind-body therapy

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Area of Science:

Epigenetics
Genomics
Molecular Biology

Background:

Epigenetic and functional genomics methods are increasingly used to study mind-body therapies.
DNA microarray technology has linked stress response pathways to disease and mind-body therapy effects.

Purpose of the Study:

To investigate the bio-molecular effects of a mind-body therapeutic protocol (MBT-T) on DNA methylation.
To analyze changes in epigenetic profiles before, during, and after MBT-T.

Main Methods:

Analysis of DNA samples from 20 individuals using the MSAP epigenetic marker.
Biostatistical analysis including Bayesian statistics (Structure) and DNA methylation level estimation (MSAP statistical tool).
Comparison of epigenetic profiles at three time points: pre-treatment, 1 hour post-treatment, and 24 hours post-treatment.

Main Results:

Bayesian analysis revealed changes in subject clustering and membership across the three time points.
Epigenetic profiles shifted from heterogeneous pre-treatment to more homogeneous clusters post-treatment.
The mind-body therapeutic protocol significantly affected the DNA epigenetic status of the subjects.

Conclusions:

Mind-body therapies can induce measurable changes in DNA methylation patterns.
The study demonstrates a convergence towards a homogeneous DNA methylation status following MBT-T.
Epigenetic modifications are a key mechanism through which mind-body therapies exert their effects.