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Cetirizine-Induced Fixed Drug Eruption.
Srija Gopal1, Selvalaxmi Gnanasegaran1, Gerard Marshall Raj1
1Sri Venkateshwaraa Medical College Hospital and Research Centre, Puducherry, India.
Journal of Research in Pharmacy Practice
|July 28, 2018
Summary
Fixed drug eruption (FDE) is a rare adverse reaction to cetirizine, a common antihistamine. This case report details a patient experiencing FDE after cetirizine use, highlighting the importance of recognizing this reaction.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Cetirizine, a second-generation antihistamine, is widely prescribed for allergic conditions like urticaria and eczema.
- Adverse drug reactions to cetirizine are uncommon, with fixed drug eruption (FDE) being particularly rare.
Observation:
- A 34-year-old female presented with itchy, hyperpigmented patches on her forearms, legs, feet, and chest.
- These lesions appeared after taking oral cetirizine for a dry cough and had recurred in similar locations two years prior.
Findings:
- The patient was diagnosed with cetirizine-induced fixed drug eruption (FDE).
- Lesions resolved slowly over 10 days with conservative management, emphasizing the delayed, cell-mediated hypersensitivity nature of FDE.
Implications:
- This case underscores that even commonly prescribed antihistamines like cetirizine can induce FDE.
- Awareness among healthcare providers is crucial for accurate diagnosis and management of FDE, especially when patients present with recurrent dermatological issues potentially linked to medication.
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