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Updated: Feb 7, 2026

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Severe panuveitis with relapsing polychondritis.

Naonori Masuda¹, Ryoko Nishikawa¹, Tetsuo Ueda¹

¹Department of Ophthalmology, Nara Medical University, Kashihara, 634-8522 Nara, Japan.

American Journal of Ophthalmology Case Reports

|July 28, 2018

Summary

This summary is machine-generated.

Relapsing polychondritis can initially present as severe panuveitis. Pars plana vitrectomy effectively treated ocular inflammation and vision loss in this rare autoimmune cartilage disease.

Keywords:

Panuveitis Pars plana vitrectomy Relapsing polychondritis Type II collagen

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Area of Science:

Ophthalmology
Rheumatology
Autoimmune Diseases

Background:

Relapsing polychondritis is a rare systemic autoimmune disease targeting cartilage.
It can manifest with diverse and severe ocular complications.

Observation:

A 53-year-old man presented with severe panuveitis and vitreous opacities, initially unresponsive to treatment.
Pars plana vitrectomy with silicone oil tamponade improved vision to 20/20.
Three years later, he was diagnosed with relapsing polychondritis, later developing panuveitis in the other eye.

Findings:

Pars plana vitrectomy with silicone oil tamponade was effective in resolving severe panuveitis and vitreous opacities.
The patient experienced significant visual acuity improvement after surgical intervention.

Implications:

Severe panuveitis with vitreous opacities may be an early indicator of relapsing polychondritis.
Ophthalmologists should consider relapsing polychondritis in patients with unexplained severe uveitis.
Vitrectomy is a valuable treatment for ocular manifestations of relapsing polychondritis.