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Updated: Feb 7, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Chemotherapy management for unfit patients with metastatic castration-resistant prostate cancer
U Anido-Herranz1, N Fernández-Núñez2, J Afonso-Afonso3
1Medical Oncology Department, Santiago University Hospital Complex (CHUS), Travesía de Coupana, s/n, 15706, Santiago de Compostela, Spain. urbanoanido@gmail.com.
Abstract:
Administration of chemotherapy in prostate cancer depends on patient fitness. In unfit patients, physiological impairment determines the optimum treatment. Although no consensus on assessing patient fitness currently exists, this article proposes an algorithm combining the available information for administering chemotherapy, and in particular docetaxel, in unfit patients. It was constructed by reviewing factors that can influence treatment, such as performance status, taxane-related comorbidities and nutritional status. Geriatric scales for prostate cancer patients and alternative treatment regimens for this population are also reviewed. In summary, patients require overall assessment to optimise treatment. Use of docetaxel should be restricted in unfit patients, and other options must be evaluated, because of high toxicity and low efficacy.
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