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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Tooth Anatomy01:21

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Related Experiment Video

Updated: Feb 7, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
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Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

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Dental Stem Cells and Tooth Regeneration.

Yi Shuai1,2, Yang Ma2,3,4, Tao Guo5

  • 1Department of Stomatology, Nanjing General Hospital of Nanjing Military Command, Nanjing, Jiangsu, People's Republic of China.

Advances in Experimental Medicine and Biology
|July 28, 2018
PubMed
Summary

Human dental stem cells offer promising regenerative potential for repairing damaged teeth and periodontal tissues. Research shows their feasibility in translational medicine for dental regeneration.

Keywords:
Dental stem cellsMesenchymal stem cellsTooth regeneration

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Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
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Area of Science:

  • Dental stem cells research
  • Regenerative medicine
  • Periodontal disease treatment

Background:

  • Dental stem cells are a subset of mesenchymal stem cells found in specialized dental tissues.
  • Established methods exist for isolating and identifying these cells.
  • Their differentiation potential makes them valuable for tooth repair.

Purpose of the Study:

  • To review human dental stem cells, including their isolation, identification, and regenerative potential.
  • To overview pathways and outcomes of regenerative research involving dental stem cells.
  • To highlight the prospects of dental stem cell-based therapies in translational medicine.

Main Methods:

  • Review of basic research, preclinical studies, and clinical trials on dental stem cells.
  • Analysis of isolation and identification techniques for dental stem cells.
  • Examination of regenerative outcomes and involved pathways.

Main Results:

  • Dental stem cells demonstrate self-renewal, multipotency, and tissue-specific differentiation.
  • These cells have shown efficiency in regenerating dental specialized structures.
  • Studies indicate improvement in the healing of periodontal diseases.

Conclusions:

  • Dental stem cells hold significant promise for regenerating teeth and periodontal tissues.
  • Regenerative medicine utilizing dental stem cells offers a viable approach for dental tissue repair.
  • These findings suggest great feasibility and prospects for dental stem cell applications in translational medicine.