Related Experiment Video
Updated: Feb 7, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Generation of Ultra-Small PLGA Nanoparticles by Sequential Centrifugation
Xingwang Wu1,2, Jiangbing Zhou1, Toral R Patel3
1Department of Neurosurgery, Yale University, New Haven, CT, USA.
Abstract:
Direct, local delivery of polymer nanoparticles to the brain is a promising strategy to bypass the blood-brain barrier (BBB) and safely deliver a large therapeutic payload. However, even with the aid of convection-enhanced delivery (CED) techniques, this approach has been limited by the inability to fabricate appropriately sized polymer nanoparticles. Here, we outline a versatile and efficient method for producing polymer nanoparticles that are <100 nm in diameter and can be delivered to the brain via CED.
Related Concept Videos
Centrifugation
Centrifugal Force
DC Generator
Next-generation Sequencing
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
Generation Time
Electric Generator: Alternator
The magnetic flux passing through the coil varies sinusoidally as the loop rotates inside the magnetic field. This...

