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Near-Infrared II Dye-Protein Complex for Biomedical Imaging and Imaging-Guided Photothermal Therapy.

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Researchers developed a novel near-infrared II (NIR-II) fluorescent dye complex for cancer theranostics. This biocompatible agent enables precise imaging and targeted therapy, offering a promising approach for clinical cancer treatment.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Biodegradable and nontoxic fluorophores are crucial for integrated cancer diagnosis and therapy.
  • Near-infrared II (NIR-II) fluorescence imaging offers high spatial and temporal resolution for biological applications.

Purpose of the Study:

  • To develop a water-soluble, biocompatible small-molecule NIR-II fluorescent dye complex for cancer theranostics.
  • To evaluate the imaging and therapeutic capabilities of the developed complex in preclinical models.

Main Methods:

  • Preparation of a novel NIR-II fluorescent dye (H2a-4T) complexed with fetal bovine serum (FBS) and Cetuximab.
  • In vivo imaging of vasculature and lymphatic systems in mice using H2a-4T@FBS.
  • Assessment of H2a-4T@Cetuximab for tumor targeting, cell-killing ability, and photothermal therapy in colorectal cancer models.

Main Results:

  • High-resolution NIR-II imaging of hind limb vasculature and lymphatic system using H2a-4T@FBS.
  • Demonstration of NIR-II imaging-guided sentinel lymph node surgery.
  • H2a-4T@Cetuximab showed effective tumor targeting and cell-killing ability in EGFR-overexpressing colorectal cancer.
  • Successful in vivo NIR-II fluorescent imaging-guided photothermal therapy of colon tumors.

Conclusions:

  • The study presents a novel molecule-protein complex theranostic agent with enhanced NIR-II signals and photothermal conversion.
  • This agent demonstrates potential for precise cancer imaging and targeted therapy, including photothermal therapy.
  • The findings suggest promising future clinical applications in cancer theranostics.