Related Experiment Video
Updated: Feb 7, 2026
06:45
Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
16.3K
[Study on Urinary Metabolic Profile in Rats with Deep Venous Thrombosis Based on Pattern Recognition]
1School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Fa Yi Xue Za Zhi
|July 28, 2018
Summary
Metabolomics identified distinct urinary biomarkers in rats with deep venous thrombosis (DVT). These findings offer potential for DVT diagnosis and forensic identification.
Area of Science:
- Biochemistry
- Metabolomics
- Urology
Background:
- Deep venous thrombosis (DVT) is a significant clinical concern.
- Accurate diagnosis and forensic identification of DVT are crucial.
- Metabolomic approaches offer novel insights into disease states.
Purpose of the Study:
- To investigate the urinary metabolic profile in a rat model of DVT.
- To identify potential small molecule biomarkers for DVT diagnosis and forensic identification.
Main Methods:
- Deep venous thrombosis (DVT) was induced in rats by inferior vena cava ligation.
- Urine samples were collected from DVT, sham, and control groups.
- Metabolic profiles were analyzed using nuclear magnetic resonance (NMR) and chemometrics (OPLS-DA).
Main Results:
- Significant differences in urinary metabolic profiles were observed between DVT, sham, and control groups.
- Partial least squares-discriminant analysis (PLS-DA) effectively distinguished the groups.
- Key metabolites including leucine, glutamine, and creatine were upregulated, while 3-hydroxybutyrate, lactate, and citrate were downregulated in DVT rats.
Conclusions:
- Urinary metabolites show promise as candidate biomarkers for DVT.
- These findings support the use of metabolomics for DVT diagnosis and forensic applications.
Related Concept Videos
01:30Venous Thrombosis I: Introduction
474
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
474
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
348
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
348
01:29Venous Thrombosis III: Interprofessional Care
373
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
373
01:30Venous Thrombosis IV: Nursing Management
268
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
268
00:52What is Metabolism?
132.0K
Overview
132.0K
01:04Venous Return
12.4K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
12.4K