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Medicinal Plants: A Complementary and Alternative Antidepressant Therapy.

Hammad Ismail1, Muhammad Ammar Amanat1, Adnan Iqbal1

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|July 28, 2018
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Herbal medicines offer promising, safer alternatives for depression treatment. This review details plant-based antidepressants, their mechanisms, and clinical trial evidence.

Keywords:
Animal modelsclinical trialsdepressionforced swimming testlearned helplessness modelneurotransmittersphytochemicalstail suspension test.

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Area of Science:

  • Pharmacology
  • Ethnobotany
  • Neuroscience

Background:

  • Depression is a complex, prevalent condition with limitations in current synthetic antidepressant treatments.
  • Herbal remedies present a potential alternative due to favorable safety profiles.
  • Focus is increasing on characterizing active plant compounds and their mechanisms of action for depression.

Purpose of the Study:

  • To review animal models used in depression research.
  • To summarize plant-derived phytochemicals with antidepressant properties and their mechanisms.
  • To detail commonly investigated medicinal plants for depression treatment.

Main Methods:

  • Literature review of animal models for depression.
  • Compilation of data on 92 medicinal plants, including origin, parts used, extraction, and active constituents.
  • Summary of clinical trials investigating herbal antidepressants.

Main Results:

  • Discussion of 21 frequently studied plants for depression.
  • Detailed list of 92 medicinal plants with relevant phytochemical information.
  • Overview of clinical evidence supporting herbal treatments for depression.

Conclusions:

  • Herbal medicine holds significant potential as a safer and effective approach to managing depression.
  • Further research into plant-based compounds and clinical validation is crucial.
  • This review provides a comprehensive resource on medicinal plants for depression.