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Updated: Feb 7, 2026

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Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent Microglia

Dafina M Angelova1, David R Brown1

  • 1Department of Biology and Biochemistry , University of Bath , Bath BA2 7AY , U.K.

ACS Chemical Neuroscience
|July 28, 2018
PubMed
Summary

Aging microglia, characterized by iron overload, contribute to increased beta-amyloid, a key factor in neurodegenerative diseases like Alzheimer's. This study introduces a novel model for brain aging research.

Keywords:
APPER stressautophagyinsulin degrading enzymemicrogliaβ-amyloid

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